/* info-pharma.de – Design 01 „Klinisch klar“ + Logo L2 „Kapsel-i“
   Raster max. 1180 px · Schrift IBM Plex Sans / Mono (lokal, SIL OFL) · keine externen Ressourcen */
/* Schriften: 4 Dateien, auf die genutzten Zeichen reduziert (tools/subset_fonts.py).
   Regular deckt 400–500 ab, SemiBold 600–700, Mono nur SemiBold. Ersatzschrift Arial mit angepassten
   Metriken, damit beim Nachladen der Webfont nichts verspringt. */
@font-face{font-family:"IBM Plex Sans";font-style:normal;font-weight:400 500;font-display:swap;src:url(/assets/fonts/plex-sans-400.woff2) format("woff2")}
@font-face{font-family:"IBM Plex Sans";font-style:italic;font-weight:400 500;font-display:swap;src:url(/assets/fonts/plex-sans-400-italic.woff2) format("woff2")}
@font-face{font-family:"IBM Plex Sans";font-style:normal;font-weight:600 700;font-display:swap;src:url(/assets/fonts/plex-sans-600.woff2) format("woff2")}
@font-face{font-family:"IBM Plex Mono";font-style:normal;font-weight:400 700;font-display:swap;src:url(/assets/fonts/plex-mono-600.woff2) format("woff2")}
@font-face{font-family:"Plex Fallback";src:local("Arial"),local("Helvetica"),local("Liberation Sans");size-adjust:100.8%;ascent-override:101.7%;descent-override:27.3%;line-gap-override:0%}

:root{--blue:#0B5CAD;--blue-d:#08458A;--blue-l:#3F8EDB;--tint:#EEF4FB;--ink:#10233F;--muted:#56677F;--line:#DCE5F0;--bg:#FFFFFF;--bg-2:#F6F9FD;
--f:"IBM Plex Sans","Plex Fallback",system-ui,-apple-system,"Segoe UI",sans-serif;--mono:"IBM Plex Mono",ui-monospace,monospace;--r:8px;--hh:76px}
*,*::before,*::after{box-sizing:border-box}
html{scroll-padding-top:calc(var(--hh) + 16px)}
body{margin:0;font-family:var(--f);color:var(--ink);background:var(--bg);font-size:17px;line-height:1.65;-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}
img{max-width:100%;display:block;height:auto}
a{color:var(--blue)}
h1,h2,h3,h4{line-height:1.15;letter-spacing:-.015em;text-wrap:balance;overflow-wrap:break-word;hyphens:auto}
:focus-visible{outline:2px solid var(--blue);outline-offset:3px;border-radius:2px}
@media (prefers-reduced-motion:reduce){*{transition:none!important}}
.wrap{max-width:1180px;margin:0 auto;padding-left:max(20px,env(safe-area-inset-left));padding-right:max(20px,env(safe-area-inset-right))}
.skip{position:absolute;left:-999px;top:0} .skip:focus{left:12px;top:12px;background:#fff;padding:8px 12px;z-index:99}

/* Header */
.site-h{position:sticky;top:0;z-index:20;background:#fff;border-bottom:1px solid var(--line)}
.bar{display:flex;align-items:center;gap:20px;height:var(--hh)}
.logo{display:inline-flex;align-items:center;gap:10px;text-decoration:none;flex:none}
.lt{font-weight:700;letter-spacing:-.01em;white-space:nowrap;font-size:20px;color:var(--ink)} .lt .h{color:var(--blue)} .lt .de{font-weight:400;color:var(--muted)}
/* Mega-Menü (Variante B): „Themen“ öffnet alle Fachseiten in drei Spalten plus Hinweis auf die neuen Fachartikel */
.nav{margin-left:auto} .tops{list-style:none;margin:0;padding:0;display:flex;gap:4px}
.nav a{color:var(--ink);text-decoration:none}
.tl{display:flex;align-items:center;gap:6px;padding:10px 14px;border-radius:6px;font-size:15px;font-weight:500;white-space:nowrap;position:relative}
.top:hover>.tl,.top:focus-within>.tl{background:var(--tint);color:var(--blue)}
.top.cur>.tl{color:var(--blue)} .top.cur>.tl::after{content:"";position:absolute;left:14px;right:14px;bottom:calc((var(--hh) - 44px) / -2 - 1px);height:3px;background:var(--blue);border-radius:3px}
.panel{position:absolute;left:0;right:0;top:var(--hh);background:#fff;border-top:1px solid var(--line);border-bottom:1px solid var(--line);box-shadow:0 24px 40px rgba(16,35,63,.12);padding-block:24px 28px;opacity:0;visibility:hidden;transition:opacity .15s,visibility .15s}
.mega:hover>.panel,.mega:focus-within>.panel{opacity:1;visibility:visible}
.pgrid{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,1.25fr) minmax(0,1.25fr) minmax(0,1fr);gap:28px}
.ch{font-size:12px;text-transform:uppercase;letter-spacing:.12em;color:var(--muted);margin:0 0 10px;padding-left:10px;font-weight:600} .ch .sh{display:none}
.col ul{list-style:none;margin:0;padding:0;display:grid;gap:2px}
.item{display:grid;grid-template-columns:46px minmax(0,1fr);gap:8px;padding:7px 10px;border-radius:7px}
.item:hover,.item[aria-current]{background:var(--tint)} .item .ab,.feat .ab{font-family:var(--mono);font-weight:600;color:var(--blue);font-size:12px} .item .ab{padding-top:3px}
.item b{display:block;font-size:14.5px;font-weight:600;line-height:1.3} .item small{display:block;color:var(--muted);font-size:12.5px;line-height:1.35}
.item[aria-current] b{color:var(--blue)}
.new{font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.06em;background:var(--blue);color:#fff;border-radius:4px;padding:1px 5px;margin-left:6px;vertical-align:1px;white-space:nowrap}
.feat{display:flex;flex-direction:column;gap:8px;background:var(--bg-2);border:1px solid var(--line);border-radius:10px;padding:14px;align-self:start}
.feat img{width:100%;aspect-ratio:16/7;object-fit:cover;border-radius:7px} .feat b{font-size:15px;line-height:1.3} .feat small{color:var(--blue);font-weight:600}
.feat:hover{border-color:var(--blue-l)}
.lang{display:flex;border:1px solid var(--line);border-radius:999px;padding:3px;font-size:13px;font-weight:600;flex:none}
.lang a{text-decoration:none;color:var(--muted);padding:4px 10px;border-radius:999px} .lang a[aria-current]{background:var(--blue);color:#fff}
.nav-toggle{position:absolute;opacity:0;pointer-events:none}
.burger{display:none;cursor:pointer;color:var(--ink);padding:6px;margin-right:-6px} .burger .c{display:none}

/* Bausteine */
.btn{display:inline-flex;align-items:center;gap:8px;background:var(--blue);color:#fff;padding:13px 22px;border-radius:6px;text-decoration:none;font-weight:600;font-size:15px;border:1.5px solid var(--blue)}
.btn:hover{background:var(--blue-d);border-color:var(--blue-d)} .btn.ghost{background:transparent;color:var(--blue)} .btn.ghost:hover{background:var(--tint)}
.eyebrow{font-size:13px;letter-spacing:.12em;text-transform:uppercase;color:var(--blue);font-weight:600;margin:0}
.card{border:1px solid var(--line);border-radius:var(--r);padding:22px;display:flex;flex-direction:column;gap:10px;background:#fff;text-decoration:none;color:var(--ink);transition:border-color .15s,box-shadow .15s}
.card:hover{border-color:var(--blue-l);box-shadow:0 8px 24px rgba(11,92,173,.10)}
.card .ab{font-family:var(--mono);font-weight:600;color:var(--blue);font-size:14px} .card h3{margin:0;font-size:19px} .card p{margin:0;color:var(--muted);font-size:15px;line-height:1.55}
.card .more{margin-top:auto;font-size:14px;font-weight:600;color:var(--blue)}
.pill{font-size:13px;font-weight:600;background:var(--tint);color:var(--blue);padding:3px 10px;border-radius:999px;text-decoration:none}

/* Footer */
.site-f{background:var(--ink);color:#C8D3E3;font-size:15px;margin-top:80px}
.site-f .cols{display:grid;grid-template-columns:1.4fr 1fr 1fr 1fr;gap:40px;padding-block:56px 40px}
.site-f h2{color:#fff;font-size:13px;letter-spacing:.12em;text-transform:uppercase;margin:0 0 12px}
.site-f ul{list-style:none;margin:0;padding:0;display:grid;gap:8px} .site-f a{color:#C8D3E3;text-decoration:none} .site-f a:hover{color:#fff;text-decoration:underline}
.site-f .about p{margin:14px 0 0;max-width:36ch} .site-f .lt{color:#fff} .site-f .lt .h{color:#fff} .site-f .lt .de{color:#9FB4D3}
.site-f .bottom{border-top:1px solid #24395A;padding-block:20px;display:flex;justify-content:space-between;gap:16px;flex-wrap:wrap;font-size:14px}

/* Startseite */
.hero{display:grid;grid-template-columns:minmax(0,1.05fr) minmax(0,.95fr);gap:56px;align-items:center;padding-block:72px 64px}
.hero h1{font-size:clamp(34px,4.6vw,56px);margin:0 0 20px;font-weight:600}
.hero .lead{color:var(--muted);max-width:58ch;margin:0} .hero .lead a{color:var(--blue)}
.btns{display:flex;gap:12px;margin-top:30px;flex-wrap:wrap}
.hero figure{margin:0;position:relative}
.hero figure>img{border-radius:12px;aspect-ratio:4/3;object-fit:cover;width:100%}
.section{padding-block:72px;border-top:1px solid var(--line)}
.head{margin-bottom:28px} .head h2{font-size:clamp(26px,3vw,34px);margin:6px 0 0;font-weight:600}
.grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:20px}
.reg{background:var(--bg-2)}
.reg .wrap{display:grid;grid-template-columns:minmax(0,.9fr) minmax(0,1.1fr);gap:56px;align-items:center}
.reg h2{font-size:clamp(26px,3vw,34px);margin:6px 0 12px;font-weight:600} .reg .wrap>div>p{color:var(--muted)}
.tree{display:grid;gap:14px}
.tree .root{background:var(--blue);color:#fff;border-radius:var(--r);padding:20px 22px;text-decoration:none}
.tree .root b{font-family:var(--mono);font-size:22px} .tree .root p{color:#D7E6F7;margin:6px 0 0;font-size:15px}
.tree .kids{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:14px;padding-left:22px;border-left:3px solid var(--blue-l);margin-left:22px}
.more-link{font-weight:600;text-decoration:none}

/* Fachartikel-Karten (Startseite) */
.grid.arts{grid-template-columns:repeat(3,minmax(0,1fr))}
.card.art{padding:0 0 22px;overflow:hidden} .card.art img{width:100%;aspect-ratio:16/7;object-fit:cover;margin-bottom:6px}
.card.art>*:not(img){margin-inline:22px}
.newart{background:var(--bg-2)}
@media (max-width:980px){.grid.arts{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media (max-width:560px){.grid.arts{grid-template-columns:minmax(0,1fr)}}

/* Tabellen, FAQ in Fachartikeln */
.article caption{caption-side:top;text-align:left;font-weight:600;color:var(--ink);padding:0 0 8px;font-size:15px}
.article thead th{background:var(--tint);color:var(--ink);font-weight:600}
.article table{margin:24px 0} .article td,.article th{vertical-align:top;min-width:140px}
.article ol li[id]:target,.article footer.footnotes [id]:target{background:var(--tint);border-radius:4px}
.article ol{font-size:15px;color:var(--muted)} .article ol li{color:var(--muted);overflow-wrap:anywhere}

/* Artikel */
.crumb{font-size:14px;color:var(--muted);padding-block:22px 0} .crumb a{color:var(--muted);text-decoration:none} .crumb a:hover{color:var(--blue)}
.crumb ol{list-style:none;margin:0;padding:0;display:flex;flex-wrap:wrap;gap:6px} .crumb li+li::before{content:"›";margin-right:6px}
.banner{margin-top:18px;border-radius:12px;overflow:hidden} .banner img{width:100%;aspect-ratio:1500/430;object-fit:cover}
.layout{display:grid;grid-template-columns:minmax(0,1fr) 280px;gap:64px;padding-top:44px}
.layout.single{grid-template-columns:minmax(0,1fr)}
.article{max-width:72ch;min-width:0}
.pills{display:flex;gap:8px;flex-wrap:wrap;margin-bottom:6px}
.article h1{font-size:clamp(32px,4vw,46px);margin:8px 0 24px;font-weight:600}
.article h2{font-size:26px;margin:44px 0 10px;font-weight:600}
.article h3{font-size:22px;margin:40px 0 10px;font-weight:600}
.article h4,.article h5{font-size:18px;margin:28px 0 8px;font-weight:600}
.article p,.article li,.article td{color:#26384F;overflow-wrap:break-word}
.article a{overflow-wrap:anywhere} .article strong{color:var(--ink)}
.article ul{padding-left:0;list-style:none;display:grid;gap:10px} .article ul>li{padding-left:28px;position:relative}
.article ul>li::before{content:"";position:absolute;left:4px;top:.62em;width:12px;height:6px;border-radius:3px;background:var(--blue);transform:rotate(-35deg)}
.article ol{padding-left:22px;display:grid;gap:8px}
.article img{border-radius:10px;margin-block:12px}
.article figure{margin:28px 0} .article figcaption{font-size:14px;color:var(--muted);margin-top:8px}
.article table{border-collapse:collapse;width:100%;font-size:15px;display:block;overflow-x:auto} .article th,.article td{border-bottom:1px solid var(--line);padding:8px 10px;text-align:left}
.article hr{border:0;border-top:1px solid var(--line);margin:32px 0}
.article sup a,.article a>sup{font-family:var(--mono);font-size:12px;text-decoration:none;background:var(--tint);padding:1px 5px;border-radius:4px;margin-left:2px;color:var(--blue)}
.article footer.footnotes{border-top:1px solid var(--line);padding-top:12px;font-size:15px;color:var(--muted);line-height:1.55}
.article footer.footnotes p{margin:10px 0 0;color:var(--muted)} .article footer.footnotes a{font-family:var(--mono);text-decoration:none;margin-right:6px}
.article .center{text-align:center}
.article img[src$="kontakt-email.svg"]{display:inline-block;height:1.3em;width:auto;margin:0;border-radius:0;vertical-align:-0.3em}
.legal-translation-note{border-left:3px solid var(--blue);background:var(--tint);padding:12px 16px;border-radius:0 var(--r) var(--r) 0;font-size:15px}
.aside .box{position:sticky;top:calc(var(--hh) + 24px);display:grid;gap:22px}
.toc{border-left:2px solid var(--line);display:grid;gap:2px;font-size:15px}
.toc b,.rel b{font-size:13px;letter-spacing:.12em;text-transform:uppercase;color:var(--muted);margin-bottom:6px;display:block}
.toc b{padding-left:14px} .toc a{text-decoration:none;color:var(--muted);padding:5px 14px;margin-left:-2px;border-left:2px solid transparent} .toc a:hover{color:var(--blue);border-color:var(--blue)}
.rel{display:grid;gap:10px} .rel .card{padding:14px 16px} .rel .card h3{font-size:16px}

/* Archive */
.archive{padding-top:44px} .archive h1{font-size:clamp(30px,3.6vw,42px);margin:0 0 28px;font-weight:600}
.entries{display:grid;gap:20px}
.entry{display:grid;grid-template-columns:240px minmax(0,1fr);gap:28px;border:1px solid var(--line);border-radius:var(--r);padding:20px;align-items:start}
.entry.noimg{grid-template-columns:minmax(0,1fr)}
.entry img{border-radius:8px;aspect-ratio:5/4;object-fit:cover;width:100%}
.entry .txt>*{margin:0 0 8px} .entry h2,.entry h3{font-size:22px} .entry h2 a,.entry h3 a{color:var(--ink);text-decoration:none} .entry p{color:var(--muted)}
.pager{display:flex;gap:10px;align-items:center;margin-top:24px;color:var(--muted);font-size:15px;flex-wrap:wrap}
.pager p{margin:0}

/* 404 */
.notfound{padding-block:80px 20px;max-width:60ch} .notfound .big{font-family:var(--mono);color:var(--blue);font-size:15px;font-weight:600}

/* Responsiv */
@media (max-width:1100px){.pgrid{grid-template-columns:minmax(0,1fr) minmax(0,1.2fr) minmax(0,1.2fr)} .feat{display:none}}
@media (max-width:900px){
 .burger{display:block} .bar .lang{margin-left:auto}
 .nav{position:fixed;inset:var(--hh) 0 0 0;z-index:30;background:#fff;overflow:auto;display:none;padding:4px max(20px,env(safe-area-inset-left)) 32px;border-top:1px solid var(--line)}
 .nav-toggle:checked ~ .nav{display:block} .nav-toggle:checked ~ .burger .o{display:none} .nav-toggle:checked ~ .burger .c{display:block}
 .tops{flex-direction:column;gap:0} .mega>.tl{display:none}
 .panel{position:static;opacity:1;visibility:visible;border:0;box-shadow:none;padding:0} .panel .wrap{padding:0}
 .pgrid{grid-template-columns:minmax(0,1fr);gap:0} .feat{display:none}
 .ch{margin:18px 0 8px;padding:0} .ch .lg{display:none} .ch .sh{display:inline}
 .col ul{grid-template-columns:minmax(0,1fr) minmax(0,1fr);gap:6px}
 .item{grid-template-columns:minmax(0,1fr);gap:2px;border:1px solid var(--line);padding:9px 10px} .item small{display:none}
 .item b{font-size:14px;overflow-wrap:anywhere;hyphens:auto}
 .top:not(.mega)>.tl{font-size:17px;font-weight:600;padding:15px 0;border-bottom:1px solid var(--line);border-radius:0}
 .top:not(.mega):first-of-type>.tl{margin-top:14px}
 .top:hover>.tl{background:none} .top.cur>.tl::after{display:none}
}
@media (max-width:980px){
 .site-f .cols{grid-template-columns:repeat(2,minmax(0,1fr))}
 .grid{grid-template-columns:repeat(2,minmax(0,1fr))} .hero,.reg .wrap{grid-template-columns:minmax(0,1fr)} .hero{padding-block:40px;gap:32px}
 .layout{grid-template-columns:minmax(0,1fr);gap:24px} .aside .box{position:static} .toc{display:none}
}
@media (max-width:640px){.entry{grid-template-columns:minmax(0,1fr)}}
@media (max-width:560px){
 :root{--hh:68px} body{font-size:16px} .site-f .cols{grid-template-columns:minmax(0,1fr)} .bar{gap:14px} .lang a{padding:4px 8px} .lt{font-size:18px}
 .grid,.tree .kids{grid-template-columns:minmax(0,1fr)} .section{padding-block:52px}
 .banner{margin-left:calc(-1 * max(20px,env(safe-area-inset-left)));margin-right:calc(-1 * max(20px,env(safe-area-inset-right)));border-radius:0} .banner img{aspect-ratio:16/7}
}
@media print{.site-h,.site-f,.aside{display:none} body{font-size:12pt}}